تأثیر تمرین تناوبی با شدت بالا بر سطوح سرمی FGF21 و مقاومت به انسولین در مردان چاق

Background: Fibroblast growth factor 21 (FGF21) plays an important role in regulation of energy metabolism and insulin resistance; however, the synergistic effects of high intensity interval training (HIIT) on FGF21 and insulin resistance are not elucidated which was focused in this study. Methods: This experimental research was conducted by pretest- posttest design with control group. In this study, 24 obese men were assigned into two groups including HIIT (n=12, age: 39.83 ± 5.63 years, weight: 100.83 ± 5.81 kg and body mass index: 32.73 ± 2.8 kg/m2) and Control (n=12, age: 39.41 ± 5.23 years, weight: 100.08 ± 4.71 kg, and body mass index: 32.34 ± 1.43 kg/m2). The HIIT group experienced eight weeks of intensive exercises (three sessions per week, four bouts in each session at the intensity of 85-90% of maximum heart rate (MHR) with 3-minute active rest intervals (at 60-50% of MHR) between exercise bouts. Blood samples were collected at baseline and also 48 hours following to the last training session. The data were compared using paired and independent samples t tests. Results: HIIT resulted in a contemporary reduction of plasma glucose and serum insulin and FGF21 and also improved HOMA index (P˂0/05). Conclusion: High intensity interval training plays an effective role in improvement of insulin resistance and reduction of serum FGF21 in obese subjects, which may be due to an improved FGF21 resistance.